Name | RG7834 |
Synonyms | RG7834 RG7834 S-isomer RG7834 (RO 7020322) 2H-Benzo[a]quinolizine-3-carboxylic acid, 6,7-dihydro-10-methoxy-9-(3-methoxypropoxy)-6-(1-methylethyl)-2-oxo-, (6S)- |
CAS | 2072057-17-9 |
Molecular Formula | C22H27NO6 |
Molar Mass | 401.45 |
Density | 1.27±0.1 g/cm3(Predicted) |
Boling Point | 578.6±50.0 °C(Predicted) |
Solubility | DMSO : 125 mg/mL (311.37 mM; Need ultrasonic) |
pKa | 5.91±0.40(Predicted) |
Storage Condition | -20℃ |
Use | RG7834 (RO 7020322) is a highly selective and orally acceptable HBV inhibitor. In dHepaRG cells, RG7834 can effectively inhibit HBV antigens HBsAg,HBeAg and HBV DNA with IC50 values of 2.8,2.6 and 3.2 nM respectively. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.491 ml | 12.455 ml | 24.91 ml |
5 mM | 0.498 ml | 2.491 ml | 4.982 ml |
10 mM | 0.249 ml | 1.245 ml | 2.491 ml |
5 mM | 0.05 ml | 0.249 ml | 0.498 ml |